Education/Professional Experience
03/2010-10/2010 Visiting Scholar , University of South California, U.S.
10/2005–10/2006 Post-doctoral fellow, RheumatismResearch Center, the Catholic University of Korea, Korea.
02/2002–08/2005 PhD, Division of Rheumatology and Immunology, Beijing University, Beijing, PR China.
09/1996–07/1999 Master of Medical Science, Division of Rheumatology and Immunology, Dalian Medical University, Dalian, PR China.
09/1987–07/1993 M.D.,Bethune Medical University,Changchun, PR China.
07/2013- Professor, Department of Immunology, College of Medical Science, Dalian Medical University
Professor,Division of Rheumatology and Immunology, Nanjing Drum Tower Hospital
09/1999 –12/2010 Division of Immunology Dalian University Medical School, Dalian, PR China
09/1993 – 07/1996 Resident,Dalian municipal Hospital, Dalian, PR China
Participation in the Academic Community
1、Liaoning Province medical microbiology and Immunology Branch Committee (2016-2020)
2、China immunology clinical branch of Youth Committee (2012-2016);
Publication
1. Ma Z, Wang B, Wang M, Sun X, Tang Y, Li M, Li F,Li X*. TL1A increased IL-6 production on fibroblast-like synoviocytes by preferentially activating TNF receptor 2 in rheumatoid arthritis. Cytokine. 2016 Apr 12; 83:92-98.IF 2.940.
2. Liu R, Li X, Zhang Z, Zhou M, Sun Y, Su D, Feng X, Gao X, Shi S, Chen W, Sun L. Allogeneic mesenchymal stem cells inhibited T follicular helper cell generation in rheumatoid arthritis. Sci Rep. 2015 Aug 11;5:12777. doi: 10.1038/srep12777. IF 5.228.
3. Liu R, Su D, Zhou M, Feng X,Li X(co-corresponding author), Sun L*. Umbilical cord mesenchymal stem cells inhibit the differentiation of circulating T follicular helper cells in patients with primary Sjogren's syndrome through the secretion of indoleamine 2,3-dioxygenase. Rheumatology (Oxford). 2015 Feb;54(2):332-42. IF 4.524.
4. Shi D,Li X(co-first author), Chen H, Che N, Zhou S, Lu Z, Shi S, Sun L*. High level of reactive oxygen species impaired mesenchymal stem cell migration via overpolymerization of F-actin cytoskeleton in systemic lupus erythematosus.Pathol Biol (Paris). 2014 Dec;62(6):382-90.IF 1.074.
5. Che N,Li X(co-first author), Zhang L, Liu R, Chen H, Gao X, Shi S, Chen W, Sun L*. Impaired B Cell Inhibition by Lupus Bone Marrow Mesenchymal Stem Cells Is Caused by ReducedCCL2 Expression. J Immunol. 2014 Nov 15;193(10):5306-14. IF4.922.
6. Zhou M, Liu R, Su D, Feng X,Li X*.TL1A increased the differentiation of peripheral Th17 in rheumatoid arthritis. Cytokine.2014 Sep;69(1):125-30. IF2.664.
7. Li X, Wang D, Liang J, Zhang H, Sun L*.Mesenchymal SCT ameliorates refractory cytopenia in patients with systemiclupus erythematosus. Bone Marrow Transplant, 2013April, 48(4):544-50.IF 3.466.
8. Li X，Wang D, Lu Z, Chen J, Zhang H, Sun L*. Answer to 'Toxicepidermal necrolysis withfailure ofre-epithelialization. Couldumbilical cord mesenchymal stem cell transplantation have arole?' J Eur Acad Dermatol Venereol, 2013July, 27(7):925. doi: 10.1111/j.1468-3083.2012.04666.x.IF3.105.
9. Li X，Wang D, Lu Z, Chen J, Zhang H, Sun L*.Umbilical cord mesenchymal stem cell transplantation indrug-induced Stevens-Johnson syndrome. J Eur Acad Dermatol Venereol, 2013 May , 27(5):659-61. IF3.105.
10. Liu R, Wu Q, Su D, Che N, Chen H, Geng L, Chen J, Chen W, Li X*(co-corresponding author), Sun L*. A regulatory effect ofIL-21 on T follicular helper-like cell and B cell inrheumatoid arthritis.Arthritis research and therapy, 2012 Nov, 23; 14(6):R255. IF4.302.
11. Li X, Liu L, Meng D, Wang D, Zhang J, Shi D, Liu H, Xu H, Lu L, Sun L*.Enhanced apoptosis and senescence of bone marrow-derived mesenchymal stem cells in patients with systemic lupus erythematosus. Stem cell Dev, 2012 Sep, 21(13):2387-94.IF4.67.
12. Che N,Li X(co-firstauthor), Zhou S, Liu R, Shi D, Lu L, Sun L*. Umbilical cord mesenchymal stem cells suppress B-cell proliferation and differentiation. Cellular Immunology, 2012, 274(1-2):46-53. IF1.743.
13. Liang J,Li X(co-firstauthor), Zhang H, Wang D, Feng X, Wang H, Hua B, Liu B, Sun L*. Allogeneic mesenchymal stem cells transplantation in patients with refractory RA. Clin Rheumatol, 2012 Jan, 31(1):157-61. IF2.037.
14. Liu Z*, Li B,Li X*(co-corresponding author), Zhang L, Lai L. Identification of Small-Molecule Inhibitors against Human Leukocyte Antigen-Death Receptor 4 (HLA-DR4) Through a Comprehensive Strategy.J Chem Inf Model. 2011 Feb, 51(2):326-34.IF4.675.
15. Li X, Kim KW, Cho ML, Ju JH, Kang CM, Oh HJ, Min JK, Lee SH, Park SH, Kim HY*. IL-23 induces receptor activator of NF-kappaB ligand expression in fibroblast-like synoviocytes via STAT3 and NF-kappaB signal pathways.Immunol Lett, 2010 Jan, 127(2):100-107. IF 2.511.
16. Li X, Li R, Li Z*. Inhibitory effects on HLA-DR1 specific T cell activation by influenza virus haemagglutinin-derived peptides. Tissue antigens, 2006 Jan, 67(1):45-52. IF 2.462.
17. Li X, Li R, Li Z*. Influenza virus haemagglutinin derived peptides inhibit T-cell activation induced by HLA-DR4/1 specific peptides in rheumatoid arthritis.Clin Exp Rheumatol, 2006 Mar, 24(54):148-154. IF 2.189.
18. Li X, Li R, Li Z*. Altered influenza virus haemagglutinin peptides inhibit T cell responses to type II collagen in rheumatoid arthritis.Ann Rheu Dis, 2005 Dec, 64(12):1790-1. IF6.956.
19. Li R,Li X(co-firstauthor), Li Z*. Altered CII263-272 peptides inhibited peripheral blood T cell activation in patients with rheumatoid arthritis. Clinical Immunology, 2006, 118: 317-323. IF3.606
20. Wang M , Wang B, Ma Z, Sun X, Tang Y,Li X, Wu X. Detection of the novel IL-1 family cytokines by QAH-IL1F-1 assay in rheumatoid arthritis. Cellular and Molecular Biology, Cell. Mol. Biol.2016, 62 (4): 31-34.IF 0.605.
Research Projects/Grants
2017-2020 Grant of National Committee of Nature Science (the first applicant，No.81671606)：Abnormal Tfh regulation mediated by decreased PEDF expressed on IL-34-stimulated synovial mesenchymal stem cell in rheumatoid arthritis
2014-2017 Grant of National Committee of Nature Science (the first applicant，No. 81373214)：The mechanism by which Umbilical Cord mesenchymal stem cell regulated Tfh proliferation and differentiation via PGE2 in rheumatoid arthritis
2012-2015 Grant of National Committee of Nature Science (the first applicant，No. 81373214)：The mechanism by whichTL1Aregulated Tfh proliferation and differentiation inthe pathogenesis ofrheumatoid arthritis
2011-2011 Grant of National Committee of Nature Science (the first applicant，No. 81172847)
The effect of TL1A-regulated Tfh proliferation and differentiation on rheumatoid arthritis
2012-2013 Grant of National Committee of Nature Science (the first applicant，No.81072473)
The regulatory effectsofTL1A and its receptors on immune cells in rheumatoid arthritis
2015-2016 Chinese Postdoctoral Science Foundation (the first applicant，No. 2012M510073)
The effect of TL1A-regulated Tfh activation on antibody production in rheumatoid arthritis
Admission Plan/Requirements
Admission Plan：One Ph.D student each year；
Requirements： good command of English；
It is better if understanding Chinese；
Mastering ofknowledge and technique in molecular biology.
