Education Background

1983.09－1988.07: Shandong Medical University, School of Public Health, Bachelor of Science 1988.09－1991.07: Shandong Academy of Medical Sciences, Occupational Health and Industrial Toxicology，Master of Science 
1995.09－1998.07: Peking Union Medical Collage, Department of Pathology，PhD in Medicine


Working Experience

1991.09－1995.08: Shandong Providence Hospital, Shangdong University, Resident    
1998.09－2002.07: Department of Pathology, Wake Forest University, USA, Post Doc
2002.08－2005.08: Cardiovascular Research Center, University of North Carolina at Chapel Hill, USA, Research Assistant
2005.09－2010.02: Department of Pathology, Peking Union Medical Collage, China, Professor
2010.03－2014.12: Department of Physiology and Pathology, Capital University of China, Professor
2015.01－Present: Institute of Cardiovascular Disease, Dalian Medical University, China,
Professor

 Research Projects

1. 2017.01-2021.12: National Science Foundation of China, Key Program. Mechanisms of chemokines/Receptors in regulating of heart failure (81630009)
2. 2014.01-2018.12: National Science Foundation of China, Key Program. Role of ubiquitination-mediated protein degradation in cardiac hypertrophy (81330003)
3. 2016.01- 2019.12: National Science Foundation of China. Mechanisms of deubiquitination UCHL1 in regulating of heart failure (31571170)
4. 2011.01-2014.2：National Science Foundation for distinguished Young Scholars. Pathophysiological mechanism of heart failure (81025001)
5. 2012.01-2017.12: The National Basic Research Program of China (973). Environmental metabolism promotes hypertension via activation of inflammatory responses (2012CB517802)
6. 2006.01-2011.12：The National Major Program. The mechanism of protein active degradation (2006CB910306)

Honors and Awards
2015：Climbing Scholar in Liaoning Provenience
2013：The National Key Talent Project (No.130009)
2012：The Ministry of education of Yangtze River scholar Professor（No.T2011160）
2010：National Science Foundation for distinguished Young Scholars


Social Positions

2015－Present: Section of Clinical Trial and Big Data Quality Control, Society of China Quality Association for Pharmaceuticals, Deputy Chair 
2015－Present: Peripheral Vessel Section, Society of Chinese Microenvironment, Committee Member
2011－Present: Lipid and lipoprotein section, Society of Chinese biochemistry and molecular biology
2014－Present: Chinese Society of Pathophysiology, Committee Member of the Eighth Session 
2014－Present: ISHR of Chinese Section, Committee Member of the Sixth Session             


Published Papers

1． Lei Wang, Xue-Chen Zhao, Wei Cui, Yong-Qiang Ma, Hua-Liang Ren, Xin Zhou, Yan-Zong Yang, Yun-Long Xia*, Jie Du, Hui-Hua Li*. Genetic and pharmacologic inhibition of the chemokine receptor CXCR2 prevents experimental hypertension and vascular dysfunction. Circulation. 2016;134:1353–1368. (IF=17.047)
2． Lei Wang, Tian-Peng Zhang, Yuan Zhang, Hai-Lian Bi, Xu-Min Guan, Hong-Xia Wang, Xia Wang, Jie Du, Yun-Long Xia*, Hui-Hua Li*. Protection against doxorubicin-induced myocardial dysfunction in mice by cardiac-specific expression of carboxyl terminus of hsp70-interacting protein. Scientific Reports. 2016; 6:28399. (IF=5.228)
3． Cai-xia Guo, Xue Jiang, Xiang-jun Zeng, Hong-xia Wang, Hui-hua Li, Feng-he Du, Bu-xing Chen. Soluble receptor for advanced glycation end-products protects against ischemia/reperfusion-induced myocardial apoptosis via regulating the ubiquitin proteasome system. Free Radical Biology and Medicine. 2016; 94:17–26. (IF=5.784) 
4． Xia Wang, Hong-Xia Wang, Yu-Lin Li, Cong-Cong Zhang, Chun-Yu Zhou, Lei Wang, Yun-Long Xia, Jie Du, Hui-Hua Li*. MicroRNA Let-7i Negatively Regulates Cardiac Inflammation and Fibrosis. Hypertension. 2015;66:776-785. (IF=6.48)
5． Nan Li, Hong-Xia Wang, Qiu-Yue Han, Jie Du, Yun-Long Xia*, Hui-Hua Li*. Activation of the Cardiac Proteasome Promotes Angiotension II-Induced Hypertrophy by Down-regulation of ATRAP. J Mol Cell Cardiol. 2015 Feb;79:303-14.（IF=4.655）
6． Yan Ma, Chen Zhang, Xiao-Bo Gao, Hai-Yan Luo, Yang Chen, Huihua Li*, Xu Ma*, Cai-Ling Lu*. Folic acid protects against arsenic-mediated embryo toxicity by up-regulating the expression of Dvr1. Scientific Reports. 2015，Nov 5;5:16093.. (IF=5.578) 
7． Hualiang Ren, Fangda Li, Cui Tian, Hao Nie, Lei Wang, Hui-Hua Li*, and Yuehong Zheng*. Inhibition of Proteasome by Low-dose bortezomib Attenuates Angiotensin II-induced Abdominal Aortic Aneurysm in Apo E-/- Mice. Scientific Reports. 2015 Oct 28;5:15730. (IF=5.578) 
8． Qiu-Yue Han, Hong-Xia Wang, Xiao-Hong Liu, Cai-Xia Guo, Qi Hua, Xiao-Hong Yu, Nan Li, Yan-Zong Yang, Jie Du, Yun-Long Xia*, and Hui-Hua Li*. Circulating E3 ligases are novel and sensitive biomarkers for diagnosis of acute myocardial infarction. Clinical Science（Lond）2015 Jun;128(11):751-60.（IF=5.598）
9． Yan Liu, Ying Wang, Hongtao Shi, Lixin Jia, Jizhong Cheng, Wei Cui, Huihua Li, Ping Li, Jie Du. CARD9 mediates necrotic smooth muscle cell-induced inflammation in macrophages contributing to neointima formation of vein grafts. Cardiovasc Res. 2015 Oct 1;108(1):148-58. (IF=5.94)
10． Hui Yang, Nan Li, Li-Na Song, Lei Wang, Cui Tian, Chao-Shu Tang, Jie Du, and Hui-Hua Li . Xiao-Hong Yu* and Hong-Xia Wang*. Activation of NOD1 by DAP contributes to myocardial ischemia/reperfusion injury via multiple signaling pathways. Apoptosis, 2015 Apr;20(4):512-22.（IF=3.685）
11． Lei Wang, Yu-Lin Li, Cong-Cong Zhang, Wei Cui, Xia Wang, Yong Xia, Jie Du*, Hui-Hua Li*. Inhibition of Toll-Like receptor 2 reduces cardiac fibrosis by attenuating macrophage-mediated inflammation. Cardiovascular Research. 2014 Mar;101(3):383-92. (IF=5.94) 
12． Wei Zhao, Yulin Li, Lili Pan, Hui-Hua Li*, Jie Du*. Atg5 deficiency-mediated mitophagy aggravates cardiac inflammation and injury in response to angiotensin. Free Radical Biology & Medicine, 2014; 69: 108-115. (IF=5.736)
13． Hong-Tao Shi, Ying Wang, Li-Xin Jia, Yan-Wen Qin, Yan Liu, Hui-Hua Li, Yong-Fen Qi, Jie Du*. Cathepsin S Contributes to  Macrophage Migration via Degradation of Elastic Fiber Integrity to Facilitate Vein Graft Neointimal Hyperplasia. Cardiovascular Research. 2014, Mar 1;101(3):454-63. (IF=5.94)
14． Yina Wu, Yulin Li, Congcong Zhang, Xi A, Yueli Wang, Wei Cui, Huihua Li, Jie Du*. S100a8/a9 Released by CD11b+Gr1+ Neutrophils Activates Cardiac Fibroblasts to Initiate Angiotensin II-Induced Cardiac Inflammation and Injury. Hypertension.2014；63:1241-1250. (IF=6.48)
15． Feifei Ma, Jin Feng, Chao Zhang,1 Yulin Li, Guanming Qi, Huihua Li, Yuzhang Wu, Yangxin Fu, Yang Zhao, Hairong Chen, Jie Du* and Hong Tang*. The Requirement of CD8+ T Cells To Initiate and Augment Acute Cardiac Inflammatory Response to High Blood Pressure. J Immunol. 2014 Apr 1;192 (7):3365-73. （IF=5.362）
16． Congcong Zhang, Yulin Li, Chunxiao Wang,  Yina Wu, Wei Cui, Takashi Miwa, Sayaka Sato,  Huihua Li,  Wen-Chao Song*,  Jie Du*. Complement C5a receptor mediates Ang II-induced cardiac inflammation and remodeling. Arterioscler. Thromb. Vasc. Biol. 2014; 34: 1240-1248.（IF=5.533）
17． Chen Chen, Yan Meng, Lei Wang, Hong-Xia Wang, Cui Tian, Guo-Dong Pang, Hui-Hua Li*, Jie Du*. Ubiquitin-activating enzyme E1 inhibitor PYR41 attenuates angiotensin II-induced activation of dendritic cells via the IkBa/NF-kB and MKP1/ERK/STAT1 pathways. Immunology. 2014 142, 307-319. (IF=3.705)
18． Hong-Xia Wang, Hui Yang, Qiuyue Han, Nan Li, Xue Jiang, Cui Tian, Jie Du*, Huihua Li*. NADPH oxidases mediate a cellular 'memory' of angiotensin II stress in hypertensive cardiac hypertrophy. Free Radical Biology & Medicine, 2013. pp. 897-907. (IF=5.71) 
19． Qin Y, Cao X, Guo J, Zhang Y, Pan L, Zhang H, Li H, Tang C, Du J, Shi GP*. Deficiency of cathepsin S attenuates angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-deficient mice. Cardiovascular Research. 2012,Dec;96 (3): 401-10. (IF=5.808) 
20． 
21． Li Y, Zhang C, WU Y, Han Y, Cui W, Jia L, Cai L, Cheng J, Li H, Du J*. Interleukin-12p35 Deletion Promotes CD4 T-Cell–Dependent Macrophage Differentiation and Enhances Angiotensin II–Induced Cardiac Fibrosis. Arterioscler. Thromb. Vasc. Biol. 2012 Jul;32(7):1662-74. （IF=5.533）
22． Yang M, Zheng J, Miao Y, Wang Y, Cui W, Guo J, Qiu S, Han Y, Jia L, Li H, Cheng J, Du J*. Serum-glucocorticoid regulated kinase 1 regulates alternatively activated macrophage polarization contributing to angiotensin II-induced inflammation and cardiac fibrosis. Arterioscler. Thromb. Vasc. Biol. 2012 Jul;32(7):1675-86.（IF=5.533）
23． Zhang Y, Zeng Y, Wang M, Tian C, Ma X, Chen H, Fang Q, Jia L, Du J, and Li H*. Cardiac-specific overxpression of E3 ligase Nrdp1 increases ischemia and reperfusion-induced cardiac injury. Basic Research in Cardiology. 2011, 106(3):371-83. （IF=5.955）
24． Kang YM#*, Gao F#, Li HH#, Cardinale JP, Elks C, Zang WJ, Yu XJ, XU YY, Qi J, Yang Q, and Francis J. NF-kB in the paraventricular nucleus modulates neurotransmitters and contributes to sympathoexcitation in the heart. Basic Research in Cardiology. 2011 Nov;106(6):1087-97. （IF=5.955） 
25． Li H*, Du J, Fan Y, Zhang M, Liu D, Li L, Lockyer P, Kang E, Patterson C, Willis MS*. The ubiquitin ligase Muscle Ring Finger-1 (MuRF1) protects against cardiac ischemia/reperfusion injury by its proteasome-dependent degradation of phospho-c-Jun. Am J Pathology. 2011. Mar;178(3):1043-58.（IF=4.522）  
26． Cheng J, Wang Y, Ma Y, Chan BT, Yang M, Liang A, Zhang L, Li H, Du J*. The Mechanical Stress-Activated Serum-, Glucocorticoid-Regulated Kinase 1 Contributes to Neointima Formation in Vein Grafts. Circulation Research. 2010; 107;1265-1274.（IF=11.089） 
27． Yang D., Xie P, Guo S, Li H*. Induction of MAPK phosphatase-1 by hypothermia inhibits tumor necrosis factor-alpha-induced endothelial barrier dysfunction and apoptosis. Cardiovascular Research. 2010 Feb 1;85(3):520-529.（IF=5.808） 
28． Xie P, Guo S, Fan Y, Zhang H, Gu D, Li H*.  Atrogin-1/MAFbx enhances simulated Ischemia/reperfusion-induced apoptosis in cardiomyocytes through degradation of MAP kinase phosphatase-1 and sustained JNK activation. J. Biol. Chem. 2009; 284(9):5488-5496.（IF=4.651）  
29． Xie P, Fan Y, Zhang H, Zhang Y, She M, Gu D, Patterson C, and Li H*. CHIP represses myocardin-induced smooth muscle cell differentiation via ubiquitin-mediated proteasomal degradation. Mol. Cell Biol. 2009; 29 (9):2398-2408.（IF=5.372） 
30． nte S. Willis, Pamela Lockyer, Nathaniel Miller, Holly McDonough, David J. Glass and Cam Patterson*. Atrogin-1 inhibits Akt-dependent cardiac hypertrophy in mice via ubiquitin-dependent coactivation of Forkhead proteins. J. Clinical Investigation. 2007;117(11): 3211–3223.（IF=13.612）
31． Hui-Hua Li, Vishram Kedar, Chunlian Zhang, Holly McDonough, Ranjana Arya, Da-Zhi Wang, and Cam Patterson. Atrogin-1/ muscle atrophy F-box inhibits calcineurin-dependent cardiac hypertrophy by participating in an SCF ubiquitin ligase complex. J. Clinical Investigation. 2004；114; 1058-1071.（IF=13.612）