关于学院

张桂信

职务: 主任医师
邮箱: zgx0109@126.com
专业: 普通外科学

Education/Working Experience

Education Experience

09/2006 – 07/2009 Ph.D. , Dalian Medical University, Dalian.

Specialty: Surgery of Integrated Traditional and Western Medicine

Project: The pathogenesis of acute biliary pancreatitis.

09/2003 – 07/2006  Master of Medicine, Dalian Medical University, Dalian.

Specialty: Surgery of Integrated Traditional and Western Medicine

05/2000 – 12/2004  Bachelor of Science, Self-study higher education examination, Liaoning Normal University, Dalian.

Specialty: Computer information management

09/1998 – 07/2003  Bachelor of Medicine, Department of Clinical Medicine, Dalian Medical University, Dalian, Liaoning province, China.

Specialty: Clinical Medicine

Professional Experience

10/2015 – present   Vice Director, Chief Surgeon, Department of Acute Abdomen Surgery, The First Affiliated Hospital of Dalian Medical University, China.

10/2013 – present   Supervisor of Postgraduate Student, General Surgery, The First Affiliated Hospital of Dalian Medical University, China.

12/2012 – 09/2015   Vice Chief Surgeon, Department of Acute Abdomen Surgery, The First Affiliated Hospital of Dalian Medical University, China.

10/2014 – 02/2015   Advanced Study, Department of Endoscopic minimally invasive surgery, Tianjin Nankai Hospital, China.


09/2010 – 11/2012   Attending Surgeon, Department of General Surgery, The First Affiliated Hospital of Dalian Medical University.

10/2009 – 08/2010   Surgical Resident, Department of General Surgery, The First Affiliated Hospital of Dalian Medical University, China

10/2008 – 04/2009   Visiting Scholar, Institute of cell and molecular biology, University of South Florida, USA.

Participation in the Academic Community

General Surgery Division of Chinese Association of Integrative Medicine

Digestion and nutrition Specialized Committee of Chinese Association for Physiological Sciences

Digestive Endoscopic Intervention Committee of Chinese Medical Doctor Association

General Surgery Division Association of Integrative Medicine of Liaoning Province

Acute Abdomen Surgery Committee of Medical Association of Liaoning Province

Publication

[1] Zhang JW, Zhang GX, Chen HL, et al. Therapeutic effect of Qingyi decoction in severe acute pancreatitis-induced intestinal barrier injury. World J Gastroenterol. 2015. 21(12): 3537-46.

[2] Luo P, Wang C, Zhang G. A rare case report of chronic cholecystitis complicated with incomplete gallbladder volvulus. Int J Clin Exp Med. 2014. 7(10): 3602-4.

[3] Zhang G, Zhang J, Shang D, Qi B, Chen H. Deoxycholic acid inhibited proliferation and induced apoptosis and necrosis by regulating the activity of transcription factors in rat pancreatic acinar cell line AR42J. In Vitro Cell Dev Biol Anim. 2015 .

[4] Zhang G, Chen H, Cao C et. al.. Cytotoxic effect of desoxycholic acid on pancreatic acinar cells and its influence on the activity of nuclear transcription factors. Chin J Exp Surg. 2011. 28(9): 1512-1514.

[5] Zhang G, Zhang J, Shang D, Qi B, Chen H. Deoxycholic acid inhibited proliferation and induced apoptosis and necrosis by regulating the activity of transcription factors in rat pancreatic acinar cell line AR42J. In Vitro Cell Dev Biol Anim. 2015. 51(8): 851-6.

[6] Zhang GX, Chen HL, Ji J, Wu YY, Shang D, Zhang L. Emodin protects from deoxycholic acid-induced AR42J cell damage. Shijie Huaren Xiaohua Zazhi 2012; 20(9):771-775.

[7] Tan Y, Bi W, Zhang GX. Role and molecular mechanism of farnesoid X receptor in obstructive jaundice. Shijie Huaren Xiaohua Zazhi 2015; 23(16): 2574-2581.

[8] Qi B, Chen HL, Shang D, Dong Y, Zhang GX, Yu L. Effects of hypoxia-inducible factor-1alpha and matrix metalloproteinase-9 on alveolar-capillary barrier disruption and lung edema in rat models of severe acute pancreatitis-associated lung injury. Exp Ther Med. 2014. 8(3): 899-906.

[9] Zhang GX, Chen HL, Gong AX, Zhang L. Relationship between pancreatic acinar cell apoptosis and acute pancreatitis and the therapeutic strategy for acute pancreatitis. Shijie Huaren Xiaohua Zazhi 2007;15(10):1115-1120

[10] Chen HL, Zhang GX, Gong AX, Zhang L. Role of acinar cell apoptosis and expression of Bax and Caspase-8 in rats with acute Necrotizing pancreatitis. Shijie Huaren Xiaohua Zazhi 2007;15(10):1067-1072

[11] Zhang Guixin, Chen Hailong, Qu Shuxian, Gong Aixia. Effects of QingYiTang Decoction on Apoptosis of Acinar Cell in Rats with Acute Necrotizing Pancreatitis. Chinese Journal of Surgery of Integrated Traditional and Western Medicine 2008; 14: 38-42.

Research Projects/Grants

1、Influence of Qingyi decoction on pancreatic acinar cell Gpbar1 signal pathway in acute biliary pancreatitis in rat. National Science Foundation of China(81303110), 2014/01-2016/12,¥230,000.00,Director.
2、The mechanism of Qingyi decoction regulates the apoptosis and necrosis in pancreatic acinar cell in acute biliary pancreatitis. Basic Research Foundation of Liaoning Province Key Lab(LZ2015028), 2015/01-2017/12,¥200,000.00,Director.
3、Significance of transcription factor in pancreatic acinar injury induced by deoxycholic acid and the influence of  Qingyi decoction. Doctoral program of the Ministry of education of China(20112105120007),2012/01-2014/12,¥80,000.00,Director.
4、Regulation mechanism of Gpbar1 and FXR in pancreatic acinar injury in acute biliary pancreatitis and the influence of  Qingyi decoction. Research Foundation of Liaoning Province Education Department(L2012328),2011/01-2013/12,¥30,000.00,Director.

Admission Plan/Requirements

Recruit 1 foreign graduate student per year.

Major in biliary and pancreatic surgery, welcome the student who also interested in Traditional Chinese Medicine, and prefer English native speakers.