Education/Working Experience

10.2015-current   Investigator, Dalian Medical University, Second Hospital, Dalian, China

02.2012-10.2015  Research Assistant Professor, University of Maryland, Baltimore, MD

02.2009-02.2012 Research Assistant Professor, Children’s National Medical Center, Washington, DC

06.2004-02.2009 Research Instructor, Georgetown University Medical Center, Washington, DC

06.2003-06.2004   Research Associate, Johns Hopkins University, Baltimore, MD

09.1999-05.2003 Visiting Fellow, Pulmonary-Critical Care Medicine Branch, NHLBI, Bethesda, MD

10.1997-08.1999 Postgraduate Research, Max-Plank Institute fur Biochemie, Martinsried, Germany

09.1994-06.1997 Ph.D. in Medical Science, Beijing Medical University, Beijing, China

07.1993-09.1994 Resident, Department of Medicine, Zhuhai Medical Center, Zhuhai, China

09.1990-06.1993 M.S. in Medical Science, Shanghai Medical University, Shanghai, China

09.1985-07.1990 M.D. in Medical Science, Bengbu Medical College, Bengbu, Anhui, China

Participation in the Academic Community

09. 2011- current American Society of Nephrology

01. 2012- current Mitochondria Research Society

03. 2012- current American Association for the Advancement of Science

Publication

1.  Lee H, Abe Y, Lee I, Shrivastav S, Huttemann M, Hopfer U, Felder RA, Jose PA, and Kopp JB. Increased mitochondrial activity in renal proximal tubule cells from young spontaneously hypertensive rats. Kidney Int 2014, 85: 561-569.

2.  Yu P, Han W, Villar VA, Yang Y, Lu Q, Lee H, Li F, Quinn MT, Gildea JJ, Felder RA, Jose PA. Unique role of NADPH oxidase 5 in oxidative stress in human renal proximal tubule cells. Redox Biol 2014, 2: 570-579.

3.  Armando I, Villar VA, Jones JE, Lee H, Wang X, Asico LD, Yu P, Yang J, Escano    CS Jr, PascuaCrusan AM, Felder RA, Jose PA. Dopamine D3 receptor inhibits the ubiquitin-specific peptidase 48 to promote NHE3 degradation. FASEB J 2014, 28:1422-1434.

4. Shrivastav S, Zhang L, Okamoto K,  Lee H, Lagranha C, Abe Y, Balasubramanyam A, Lopaschuk GD, Kino T, and Kopp JB. HIV Vpr enhances PPARβ/δ-mediated transcription, increases PDK4 expression and reduces PDH activity. Mol Endocrinol 2013, 27: 1564-1576.

5.  Villar VM, Jones JE, Armando I, Asico LD, Escano CS, Lee H, Wang X, Yang Y, Pascua-Crusan AM, Palmes- Saloma CP, Felder RA, and Jose PA. Sorting nexin 1 loss results in D5 dopamine receptor dysfunction in human renal proximal tubule cells and hypertension in mice. J Biol Chem 2013, 288: 152-163.

6.  Lu Q, Yang Y, Villar VA, Asico L, Jones JE, Yu P, Li H, Weinman EJ, Eisner GM, Jose PA. D(5) dopamine receptor decreases NADPH oxidase, reactive oxygen species and blood pressure via heme oxygenase-1.Hypertens Res. 2013, 36: 684-690.

7.  Villar VA, Armando I, Sanada H, Frazer LC, Russo CM, Notario PM, Lee H, Comisky L, Russell HA, Yang Y, Jurgens JA, Jose PA, Jones JE. Novel role of sorting nexin 5 in renal D1 dopamine receptor trafficking and function: implications for hypertension. FASEB J. 2013, 27: 1808-1819.

8.  Yu P, Han W, Villar VA, Li H, Arnaldo FB, Concepcion GP, Felder RA, Quinn MT, and Jose PA. Dopamine D1 receptor-mediated inhibition of NADPH oxidase activity in human kidney cells occurs via protein kinase A-protein kinase C cross talk. Free Radic Biol Med 2011, 50: 832-840.

9. Li H, Yu P, Sun Y, Felder RA, Periasamy A, and Jose PA. Actin cytoskeleton-dependent Rab GTPase-regulated angiotensin type I receptor lysosomal degradation studied by fluorescence lifetime imaging microscopy. J Biomed Optics 2010, 15: 056003 (1-9).

10. Wang X, Luo Y, Escano CS, Yang Z, Asico L, Li H, Jones JE, Armando I, Lu Q, Sibley DR, Eisner GM, and Jose PA. Upregulation of renal sodium transporters in D5 dopamine receptor-deficient mice. Hypertension 2010, 55: 1431-1437.

11. Li H, Han W, Villar VA, Keever LB, Lu Q, Hopfer U, Quinn MT, Felder RA, Jose PA, and Yu P. D1-like receptors regulate NADPH oxidase activity and subunit expression in lipid raft microdomains of renal proximal tubule cells. Hypertension 2009, 53: 1054-1061.

12. Li H, Yu P, Felder RA, Periasamy A, and Jose PA. Angiotensin II-induced angiotensin II type I receptor lysosomal degradation studied by fluorescence lifetime imaging microscopy. SPIE Proc, 2009, 7183: 71832G (1-12).

13. Li H, Armando I, Yu P, Escano C, Mueller SC, Asico L, Pascua A, Lu Q, Wang X, Villar VA, Jones JE, Wang Z, Periasamy A, Lau YS, Soares-da-Silva P, Creswell K, Guillemette G, Sibley DR, Eisner G, Gildea JJ, Felder RA, and Jose PA. Dopamine 5 receptor mediates Ang II type 1 receptor degradation via a ubiquitin proteasome pathway in mice and human cells. J Clin Invest 2008, 118: 2180-2189.

14. Li H, Li HF, Felder RA, Periasamy A, and Jose PA. Rab4 and Rab11 coordinately regulate the recycling of angiotensin II type I receptor demonstrated by fluorescence resonance energy microscopy. J Biomed Optics 2008, 13: 031206 (1-10).

15. Han W, Li H, Villar VA, Pascua AM, Dajani MI, Wang X, Natarajan A, Quinn MT, Felder RA, Jose PA, and Yu P. Lipid rafts keep NADPH oxidase in the inactive state in human renal proximal tubule cells. Hypertension 2008, 51: 481-487.

16. Ladasky JJ, Boyle S, Seth M, Li H, Pentcheva T, Abe F, Steinberg SJ, and Edidin M. Bap31 enhances the endoplasmic reticulum export and quality control of human class I MHC molecules. J Immunol 2006, 177: 6172-6181.

 17. Zeng C, Wang Z, Li H, Yu P, Zheng S, Wu L, Asico D, Hopfer U, Eisner GM, Felder RA, and Jose PA. D3 dopamine receptor directly interacts with D1 dopamine receptor in immortalized renal proximal tubule cells. Hypertension 2006, 47: 573-579.

 18.Xu KF, Shen X, Li H, Pacheco G, Moss J, and Vaughan M. Interaction of BIG2, a brefeldin A-inhibited guanine nucleotide-exchange protein, with exocyst protein Exo70. Proc Natl Acad Sci USA 2005, 102: 2784-2789.

19. Li H, Adamik R, Pacheco G, Moss J, and Vaughan M. Protein kinase A anchoring (AKAP) domains in brefeldin A-inhibited guanine nucleotide exchange protein 2 (BIG2). Proc Natl Acad Sci USA 2003, 100: 1627-1632.

20. Muller-Taubenberger A, Lupas AN, Li H, Ecke M, Simmeth E, and Gerisch G. Calreticulin and calnexin in the endoplasmic reticulum are important for phagocytosis. EMBO J 2001, 20: 6772-6782. 

21.李和旺， 韩启德. α1-肾上腺素受体的信号转导.生理科学进展 1998, 29: 17-23.

22.李和旺, 耿秋明, 张幼怡, 韩启德.α1-肾上腺素受体亚型介导细胞内游离Ca2+增高的信号转导途径．生理学报 1998, 50: 349-354.

23.李和旺, 陈明哲, 韩启德. 现代科学技术革命改变了心血管病学面貌．中华医史杂志  1997, 27: 18-23.

24.李和旺，韩启德．创造性思维与医学发展. 高等医学教育研究进展 1997, 65-66.

25.李和旺，韩启德. 细胞外Ca2+内流入胞质的机制．生理科学进展 1996, 27: 307-312.

26.李和旺，何梅先, 浦寿月, 童步高，陈灏珠. 急性下壁心肌梗塞预后分析.临床心血管病杂志1996, 12: 71-74.

27.李和旺，何梅先, 浦寿月, 童步高，陈灏珠. 急性下壁心肌梗塞并发心电图胸前导联ST段压低的 临床和预后分析．临床心血管病杂志(suppl) 1995, 11: 85-88.

28.李和旺，王宪，韩启德. 细胞内贮存钙释放的机制．生理科学进展 1995, 26: 209-212.

29.李和旺(何梅先审校). 壁冠状动脉与心肌桥的诊疗现况．上海医学 1994, 17: 174-176.

Research Projects/Grants

Research Projects:

The National Nature Science Foundation of China: “Roles of pyruvate dehydrogenase complex in the renal proximal tubule on the regulation of sodium reabsorption and hypertension”, #81670698, 2017.1-2020.12
 
The Ministry of Education of Liaoning Province: “Effect of dichloroacetate on the renal proximal tubule cytotoxicity caused by quantum dots” (L2016020), 2016.7-2020.6
 
"Intracellular trafficking of G protein-coupled receptors in renal proximal tubule cells"

Admission Plan/Requirements

Same as the university general admission requirements and plan.